VEGFA and neoplasm: While tumor volume largely increased in untreated animals over time (mean tumor volumes on days 6, 8 and 10: 25.6 mm3, 46.2 mm3 and 71.6 mm3; p <  0.0001 between each time point; Table 1; Fig. 4a), tumor volume initially remained stable during anti-VEGF treatment and only significantly increased 10 days after tumor implantation (mean tumor volumes on days 6, 8 and 10: 12.1 mm3, 16.0 mm3 and 19.6 mm3; p = 0.02 when comparing the first to the last time point, with no significant differences for all other comparisons; Table 1; Fig. 4a).