In 26 paired Taiwanese CRC patients, the Illumina Infinium HumanMethylation450 BeadChip array found three methylation differences in the ΔAvg _β (βTumor–βNormal) between paired CRC tumor and adjacent normal tissues at of the cg16601494, cg15487867, and cg16306898 sites, and the ΔAvg _β values at these sites were 0.47, 0.45, and 0.41, respectively, in the promoter and exon regions of the TMEM240 gene. Here, TMEM240 is linked to colorectal carcinoma.