To further determine alterations in TMEM240 hypermethylation and mRNA expression in Western CRC patients, we first analyzed the TCGA data of 38 CRC tumors, 38 matched normal tissues, and 314 CRC tumor tissues that had been analyzed with an Illumina Infinium HumanMethylation450 BeadChip array and displayed the methylation levels with a heatmap. Here, TMEM240 is linked to colorectal carcinoma.