A Cox proportional hazards survival analysis further adjusted for sex, age, tumor stage, tumor location, and differentiation showed that TMEM240 promoter hypermethylation and low mRNA expression were significantly and independently associated with OS, CSS, and recurrence-free survival (RFS) (Table 2, p = 0.028, 0.025, and 0.045, respectively). This evidence concerns the gene TMEM240 and neoplasm.