CRC patients with low mRNA expression of the TMEM240 gene had relatively lower overall survival (OS) and cancer-specific survival (CSS) rates than CRC patients with high mRNA expression of TMEM240 (p = 0.048 and 0.026, respectively) according to Kaplan-Meier survival curves and a log-rank test of 78 Taiwanese CRC patients, and this was especially true in female, stage IV and younger CRC patients (Fig. 4c, Figure S5, p = 0.021, 0.008, and 0.009, respectively). Here, TMEM240 is linked to cancer.