For the analysis of the relative period of activity, onset age, time to initiation of therapy, number of the affected joints, splenomegaly, serositis as well as the number of MEFV variants went into the multiple linear regression model (p value was 0.192, 0.103, 0.0.006, 0.195, 0.048 and 0.060 respectively). Here, MEFV is linked to Splenomegaly.