It’s widely believed that dysregulation of the innate immune system is the important pathogenesis for systemic juvenile idiopathic arthritis (sJIA), especially the overexpression of pro-inflammatory cytokines, such as IL-1β and IL-18 [1, 2], whose maturation and secretion primarily depend on inflammasome. The gene discussed is IL18; the disease is systemic-onset juvenile idiopathic arthritis.