As shown, the CC genotype of ERCC2-rs238406 and C allele of ERCC2-rs13181 were associated with a significantly increased risk of CRC, with odds ratios (95% CI) of 1.5 (1.1–2.0) and 1.4 (1.0–1.9), respectively (Table 3). The gene discussed is ERCC2; the disease is colorectal carcinoma.