Additionally, the ratio of Bcl2/Bax in CIP significantly decreased after MCAO operation (t = 8.347, P = 0.000, MCAO + Sham vs Control + Sham; t = 5.025, P = 0.000, MCAO + tDCS vs Control + tDCS), and tDCS dramatically increased this ratio in MCAO + tDCS group, compared with MCAO + Sham group (t = 5.033, P = 0.001; Fig. 4c). Here, BCL2 is linked to hereditary sensory and autonomic neuropathy.