LINC00346 expression was remarkably upregulated in primary NPC samples when compared with respective healthy surrounding tissues (figure 1a), and a similar upregulated expression trend was also confirmed in the four NPC cell lines (SUNE1, HNE1, C666 and CNE2) and NP69 nasopharyngeal epithelial cell line (figure 1b) (p < 0.01). This evidence concerns the gene PRECSIT and nasopharyngeal carcinoma.