HNE1/DDP and CNE2/DDP cells transfected with LINC00346 siRNAs were treated with different doses of cisplatin for 48 h to determine the IC50, which indicated that LINC00346 siRNAs transfection could sensitize NPC cells to cisplatin (figure 2e) with increased apoptotic rate determined by Caspase-3 activity assay (figure 2f) and histone/DNA ELISA test (figure 2g). This evidence concerns the gene CASP3 and nasopharyngeal carcinoma.