VEGFR-1 played significant role in tumorigenesis and progress of many cancer types as well as the GC (Zhu et al., 2015; Dziobek et al., 2019), the iVR1 decorated NPs-Apa/Sal (iVR1-NPs-Apa/Sal) was therefore supposed to able of targeting deliver the loaded drugs to gastric tumor site. Here, ENPEP is linked to gastric cancer.