Quantification of the number of antigen-specific peptide pulsed target cells revealed that the in vivo CD8+ T cell cytotoxicity was significantly higher in Enpp2+/- mice (2-fold increase in cell killing) compared to wild type C57BL/6 mice, suggesting that systemic levels of LPA can modulate anti-tumor immune response [43]. Here, ENPP2 is linked to neoplasm.