Not much is known in terms of the function of ATX-LPA-LPAR signaling in tumor infiltrating B lymphocytes (TIBLs) except an earlier study by Yang et al. in 1999 where they discovered that non-small-cell lung cancer biopsies had a significant infiltration of CD20+ TIBLs, which showed intense staining of ATX compared to adjacent normal bronchial epithelium [100]. This evidence concerns the gene ENPP2 and neoplasm.