LPAR1 and colorectal carcinoma: On the contrary, in colorectal cancer (CRC), silencing 1-acylglycerol-3-phosphate O-acyltransferase 4 (Agpat4) induced the production of LPA from CRC cells and consequently polarized peritoneal macrophages in a M1 phenotype through LPAR1 and LPAR3.