TNF and endothelial dysfunction: Our findings are in line with the ability of TNF-α to induce inflammatory response and interleukins release [48,49]; oxidative stress [47,50]; and MAPK activation [48,51] at a vascular level and bring to light new findings related to the field of natural compound and their possible use in the modulation of endothelial dysfunction induced by several stressor [22,23,52].