In a murine EAE model of MS, autoreactive T lymphocytes recognize their target autoantigens—such as MBP, MOG, or proteolipid protein—as peptide fragments presented by major histocompatibility complex (MHC) molecules, become activated, and move to the CNS parenchyma, thereby causing myelin sheath destruction. The gene discussed is HLA-C; the disease is myeloid sarcoma.