To determine the effect of the combined MAPK signaling inhibition and sesamin treatment on the motility of human oral cancer cells, HSC-3 and FaDu cells were pretreated with or without SB203580 (p38 inhibitor) and SP600125 (JNK inhibitor) for 1 h and then treated with sesamin (40 μM) for 24 h. This evidence concerns the gene MAPK8 and lip and oral cavity carcinoma.