It is now known that a subgroup of patients with severe COVID-19 have had a CSS that occurred 7–10 days after the disease onset, coinciding with the peak of respiratory distress [14,15,116,117]; immune dysregulation, rather than the level of peak viremia, is responsible for the SARS-CoV-2 infection driving a too-little-and-too-late type-I-interferon response accompanied by aberrant proinflammatory cytokine secretion by alveolar macrophages and subsequent CD4+ and CD8+ T-cell dysfunction. This evidence concerns the gene CD8A and COVID-19.