GPER1 and ovarian neoplasm: In non-genomic signaling, BPA binds GPR30 and mER and induces the activation of these receptors, evoking rapid estrogenic signaling activating kinase systems (i.e., protein kinase-A (PKA), MAPK, phosphoinositide 3-kinases (PI3K)) and modulating cAMP, protein kinase-C (PKC) and intracellular calcium levels in ovarian tumor cells [89].