In the CP group with severe phenotype, IL-10 ATA/GCC genotypes were associated with higher risk of either periodontitis development or bone decay in comparison with IL-10 ATA/ACC-ATA/ATA-ACC/ACC genotypes, with a statistically significant risk coefficient (OR: 7, 95%CI, 2.83–60.25, p < 0.05). Here, IL10 is linked to periodontitis.