FGFR3 and neoplasm: Sample collection of urine and tumours from 103 patients. Extraction of genomic DNA was performed by QIAamp Viral RNA® Mini kit. Multiplex PCR Kit were used to amplification. Snapshot ® kit was used to detect FGFR3 eight most frequent mutations hotspots in tumour tissues and urinary cells (two independent analysis were carried out). Statistical test was performed using SPSS software®, version 17.