Sample collection of urine and tumours from 103 patients. Extraction of mRNA was made by Micro mRNA Purification Kit. Then Verso Kit® were used to reverse transcription, amplification was performed by PCR PrimeStar®. FASAY assay was used to detect TP53 mutations in tumour tissues and urinary cells. Statistical test was performed using SPSS software®, version 17. The gene discussed is TP53; the disease is neoplasm.