However, while the frequencies of CD57+ Vδ2+ do not generally increase with aging, a recent study by Bruni et al. 2019 shows that elderly (>60 years old) liver metastatic colorectal cancer patients reveal significantly higher frequencies of CD57+ Vδ2+, in both the periphery and the liver, after undergoing chemotherapy, as compared to younger patients [128]. This evidence concerns the gene B3GAT1 and metastatic colorectal cancer.