In relation to COVID-19, intensive care unit (ICU) patients had higher plasma levels of pro-inflammatory cytokines, including IL-2, IL-7, IL-10, GSCF, IP10, MCP-1, MIP-1A, and TNF-α, compared with non-ICU patients [48], suggesting the emergence of a robust immune-inflammatory response in severe symptomatic COVID-19 patients. This evidence concerns the gene TNF and COVID-19.