ATP2A3 and lung adenocarcinoma: Whereas normal bronchial epithelium expresses high levels of SERCA3, expression in various lung adenocarcinoma tumors and cell lines was variable and often decreased or lost, and the induction of differentiation of the cell lines by short chain fatty acids or post-confluent growth led to enhanced SERCA3 expression, whereas the expression of SERCA2 was not modified significantly [140].