Moreover, the loss of SERCA3 expression in colon as well as gastric carcinoma cell lines could also be reversed in vitro by various cell differentiation-inducing treatments such as short chain fatty acids, other highly active histone deacetylase inhibitors or post-confluent growth, and this was accompanied by the induction of expression of various other phenotypic markers of epithelial differentiation [126,204,207]. This evidence concerns the gene ATP2A3 and gastric carcinoma.