ATP2A3 and acute promyelocytic leukemia: These observations when taken together indicate that the induction of SERCA3 expression is part of the differentiation program of acute promyelocytic leukemia cells, that a functional crosstalk exists between ER-dependent calcium sequestration and the control of acute promyelocytic leukemia cell differentiation, and illustrate the possibility of drug repurposing as SERCA inhibitors.