These data show that SERCA3 expression is part of the normal gene expression program of mature choroid plexus epithelial cells, that SERCA3 expression is lost already in benign choroid plexus tumors and that SERCA3 immunohistochemistry may be useful to distinguish hyperplastic lesions from papillomas in the choroid plexus. This evidence concerns the gene ATP2A3 and choroid plexus neoplasm.