Humans carrying mutations in one SERCA2 allele develop Darier disease, a dermatological condition characterized by impaired keratinocyte adherence and maturation [155,173], whereas mouse heterozygous SERCA2 knock-out leads to increased incidence of tumors, including carcinomas, of the keratinizing epithelium [174,175]. Here, ATP2A2 is linked to Darier disease.