In rat models of HCC, hepatic CSCs-derived exosomes displayed protumor functions, influencing apoptosis, angiogenesis, metastasis and invasiveness, as well as EMT of tumor cells, via altering the expression of targeted molecules, such as p53, Bcl2, VEGF, TGF-β and matrix metalloproteinase (MMP)-9 [122]. The gene discussed is MMP9; the disease is neoplasm.