In line with this, TGF-β, as well as C1q- and semaphorins-containing exosomes secreted by human and mouse tumor-educated mesenchymal stem cells, drive accelerated breast-cancer progression by inducing differentiation of M-MDSCs into immunosuppressive PDL-1+CD206+Arg1+IL-10+ M2-polarized macrophages [118]. This evidence concerns the gene TGFB1 and neoplasm.