HOX transcript antisense RNA (HOTAIR) silencing leads to a downregulation of TGF-β, Snail, Vimentin, p-AKT, p-APK, and CyclinD1 and an upregulation of E-cadherin, PTEN, and P27, causing the inhibition of EMT in BC cells [159]. The gene discussed is PTEN; the disease is breast cancer.