Interestingly, it was described that IFN-α15 and IFN-α16 downregulated expression of MHC class I [19], and we observed that infection attenuated NH/P68, but not virulent 22653/14, resulted in MHC I downregulation in either moMΦ or moDC [13,14,15,16,17,18,19,20,21,22,23]. This evidence concerns the gene IFNA16 and infection.