NFKB1 and Hyperglycemia: In addition, the increased level of glucose in circulation is a prerequisite to increased oxidation of glucose in the pentosophosphate pathway in mononuclear cells of girls with PCOS, IR and hyperglycemia, that is also associated with activation of the NF-KB signaling pathway and an increased level of proinflammatory cytokines IL-6, TNF-α, and ROS production by immune cells [2].