A human phase II clinical trial using an anti-CXCL10 monoclonal antibody (MDX-1100) for rheumatoid arthritis patients who had an inadequate response to methotrexate treatment showed that blocking CXCL10 significantly increased the response rate compared to that in the placebo group, suggesting a possible therapeutic use in humans [34]. The gene discussed is CXCL10; the disease is rheumatoid arthritis.