MDM2 and cancer: Interestingly, the same research group also found that in the conditions of serine and glycine deprivation and oxidative stress, MDM2 is modulated by pyruvate kinase M2 (PKM2), a key glycolytic enzyme, and controls serine/glycine metabolism and supports cancer growth by regulation of the glutathione metabolism, oxidized nicotinamide adenine dinucleotide (NAD)/reduced nicotinamide adenine dinucleotide (NADH) ratio, and ROS levels, independent of p53 [94,95].