AFP and hepatocellular carcinoma: In a recent study [37] aiming at an investigation of the possible correlation between high tumor expression of MDM2 and NFAT1 and a poor prognosis in 254 HCC patients, tissue microarrays (TMAs) were examined, revealing that as high as 60.6% of the HCC cases had high MDM2 expression, and the overexpression of MDM2 was significantly associated with several factors indicating an aggressive clinicopathological course, such as a high alpha-fetoprotein (AFP) level, large tumor size, intensive vascular invasion, and higher tumor stage [37].