NFATC2 and hepatocellular carcinoma: Extensive immunohistochemistry (IHC) studies have demonstrated that the levels of both NFAT1 and MDM2 proteins in human hepatocellular carcinoma (HCC) tumor tissues are significantly higher than that of adjacent normal liver tissues, with a positive correlation between the NFAT1 and MDM2 levels being observed in tumor tissues [12].