NFE2L2 and Alzheimer disease: Several studies indicate that consumption of HFD in AD mice elevates Aβ accumulation, which induces oxidative stress via down-regulation of nuclear factor erythroid 2-related factor 2 (Nrf-2) signaling, inhibition of antioxidant enzymes such as superoxide dismutase, and induction of lipid peroxidation in the brain [49,50].