TNF and type 2 diabetes mellitus: Single clinical studies performed in T2D patients suggest that the combined exercise seem to have more significant anti-inflammatory effects than aerobic or resistance exercise alone causing a more significant decrease in CRP, IL-6, IL-1β, TNFα, leptin, and resistin levels and a higher increase in anti-inflammatory cytokines such as IL-4, IL-10, and adiponectin [108].