TNF and type 2 diabetes mellitus: T2D patients are characterized by the elevated concentrations of cytokines belonging to Th1 responses (such as e.g., IFN-γ and TNFα) with a relative suppression of Th2 and Tregs-related immunosuppressive cytokines (such as e.g., IL-4, Il-10, and IL-10, IL-35, respectively).