Similarly, in The Optimal Trial in Myocardial Infarction with the Angiotensin II Antagonist Losartan (OPTIMAAL) trial [19], 30-day adjusted mortality risk was significantly higher (OR 3.83) in AMI patients who were admitted in sinus rhythm and developed AF during hospitalization than in those without this arrhythmia. Here, AGT is linked to cardiac arrhythmia.