Another hint in the track for the identification of the regulatory role of TNFR2 came from the observation that polymorphisms of TNFR2 were often associated with increased inflammation in chronic autoimmune diseases and in GvHD (the latter being a common adverse effect of allogeneic bone marrow transplantation) [86]. The gene discussed is TNFRSF1B; the disease is graft versus host disease.