TTR and cardiomyopathy: Amyloid structures derived from wild-type (WT)-TTR can deposit in the heart and peripheral nerves causing senile systemic amyloidosis (SSA), whereas over 100 TTR mutants were shown to be implicated in three other groups of diseases, namely familial amyloidotic polyneuropathy (FAP), cardiomyopathy (FAC), and central nervous system selective amyloidosis (CNSA).