CASP3 and mesothelioma: Further, its main derivative 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) was found to inhibit Hsp90 and multiple tyrosine kinases (HER3, AXL, MET and EGFR), and increased p27 and caspases 3/7 in mesothelioma cell lines [24].