These pro-inflammatory cytokines causes subsequent acute inflammatory responses, i.e., leukocytosis (neutrophilia) by inducing granulocyte colony-stimulating factor (G-CSF) and chemokines (abbreviated from chemotactic cytokines) such as IL-8 and monocyte chemotactic protein (MCP)-1 [1,4,5,11,13]. This evidence concerns the gene CSF3 and Increased total leukocyte count.