Suppression of the Na(+)-K(+)-2Cl(-) cotransporter, NKCC1, and the trauma-/ischemia-induced SUR1-regulated NC(Ca-ATP) (SUR1/TRPM4) channel by bumetanide and glibenclamide, respectively, show reduction of capillary failure in rats following TBI and ischemia [107]. The gene discussed is TRPM4; the disease is ischemia.