Mutations in EGFR (either small in-frame deletions in exon 19, del19, or amino acid substitution (leucine to arginine at codon 858, L858R) clustered around the ATP-binding pocket of the tyrosine kinase domain) are present in 10–26% of NSCLC and are more frequent in the Asiatic population [30]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.