For example, overexpression of HSP27 protected colon cancer cells (CaCo-2) and resistant squamous cell carcinoma cells (SCC-13) from the PDT effect (PS: MAL), modulating autophagy as a survival mechanism, whereas the suppression of the expression of this protein contributed to the inhibition of autophagy and the promotion of apoptosis [65]. The gene discussed is HSPB1; the disease is squamous cell carcinoma.