Among men, in the fully adjusted models, an increase by one SD in adiponectin levels was associated with a 10% decrease in risk of MetS (HR per SD: 0.90, 95% CI: 0.85–0.95), while leptin and LA ratio was associated with a 5% (HR per SD: 1.05, 95% CI: 1.01–1.08) and 40% (HR per SD: 1.40, 95% CI: 1.22–1.62) increase in MetS risk, respectively. Here, ADIPOQ is linked to metabolic syndrome.