TWIST is associated with different signaling cascades, like TGFβ and v-akt oncogene homolog (AKT)/phosphoinositide 3-kinase (PI3K), to promote cancer cell invasion and metastasis with the help of B lymphoma Mo-MLV insertion region 1 homolog (BMI1) and v-akt oncogene homolog 2 (AKT2) [77,78]. This evidence concerns the gene TWIST1 and cancer.