These studies were based on target-next generation sequencing and detected somatic variants in well-known cancer driver genes, including TP53, CDH1, NOTCH2, MYH9, BRCA2, ERBB4, POLE, FGFR3, ROS1, NOTCH4, LAMA2, EGFR, BRCA1, TP53, BP1, ESR1, THBS1, CASP8, and NOTCH1 [45,46]. The gene discussed is TP53; the disease is cancer.