CD5 and periodontitis: For the first time, B10-rich CD1dhi CD5+ B cells were adoptively transferred to mice with experimental periodontitis and the findings demonstrated that B10-rich CD1dhi CD5+ B cells significantly inhibited RANKL production, periodontal inflammation and bone loss in a mouse model of experimental periodontitis, suggesting the regulatory role of B10 cells in the amelioration of periodontitis pathogenesis [155].