INS and Insulin resistance: However, interestingly, XBP1 absence in the liver protected against insulin resistance [235]; in contrast, another study documented that XBP1s functions as an anti-lipogenic factor through suppression of genes involved in the synthesis of hepatic triglyceride and diacylglycerol in livers of diet-induced obese and insulin-resistant ob/ob mice and also by enhancing lipolysis [236].