When quercetin was given (0.1%; w/w in diet) to human CRP transgenic mice, a humanized inflammation model, and ApoE*3Leiden transgenic mice, a humanized atherosclerosis model, it halted IL-1b-induced CRP expression in the first and lowered the burden of atherosclerosis (40%) in the second through a reduction of circulating inflammatory markers, “serum amyloid A proteins” and fibrinogen. The gene discussed is IL1B; the disease is atherosclerosis.