EPHA3 and glioblastoma: An ADC directed against EphA3 based on the IIIA4 mAb, and utilizing the microtubule inhibitor maytansine (IIIA4-USAN), was highly effective in killing GBM cells in vitro, and potently inhibited growth of multiple GBM tumor models in mice, where the naked antibody had little effect [48].