ERBB2 and breast cancer: As mentioned above, cross-talk between EphA2 and the RTK erbB2 was found to promote tumorigenesis and metastasis in mice [15], and in accordance EphA2 expression in human breast cancers was found to correlate with resistance to trastuzumab, and co-treatment with the EphA2 antibody 3F2-3M was shown to restore trastuzumab sensitivity in mice [73].