These results suggested that glioma samples were more likely enriched of macrophages of M0 phenotype, and the samples with higher EFEMP2 expression, which are the most malignant glioma (Figures 1, 2 showed the malignant phenotype of the samples with higher EFEMP2 expression), were particularly prone to exhibit M0 features. Here, EFEMP2 is linked to central nervous system cancer.