In PD mice injected with MPTP + LV-oe-HOTAIR + agomir-NC, the ratios of LC3B-I/LC3B-II and LAMP1/LAMP2 were increased and the P62 expression was reduced compared to the PD mice injected with MPTP + LV-oe-NC + agomir-NC (p < 0.05). The gene discussed is LAMP1; the disease is Parkinson disease.