Meanwhile, the ratios of LC3B-I/LC3B-II and LAMP1/LAMP2 were lower in PD mice injected with MPTP + LV-oe-HOTAIR + miR-221-3p agomir than that detected in PD mice injected with MPTP + LV-oe-HOTAIR + agomir-NC, while the P62 expression was higher (p < 0.05). Here, LAMP1 is linked to Parkinson disease.