Whereas, the positive expression rate of NPTX2 protein in the SNc tissues of PD mice injected with MPTP + LV-oe-HOTAIR + agomir-NC was much higher than that injected with MPTP + LV-oe-NC + agomir-NC, while the positive expression rate of NPTX2 in the SNc tissues of PD mice injected with MPTP + LV-oe-HOTAIR + miR-221-3p agomir was lower than that observed in PD mice injected with MPTP + LV-oe-HOTAIR + agomir-NC (all p < 0.05) (Figure 6C). The gene discussed is NPTX2; the disease is Parkinson disease.