In concert, co-injection with M-BKO macrophages led to a reduction in the CD8+ T cell population among tumor-infiltrating CD45+ leukocytes, as well as to functionally primed CD8+ T and NK cells that expressed Ifn-γ protein following stimulation with phorbol myristate acetate and ionomycin ex vivo (Figure 7B). Here, IFNG is linked to neoplasm.