In univariate Cox proportional hazard models, significant risk predictors included unstable CHF (P = .02), an arrhythmia detected by auscultation (P = .02), gallop sounds (P = .03), increased LA/Ao ratio (P = .007), and increased serum AGP concentration (P = .007; Table S3). The gene discussed is ATP5MK; the disease is cardiac arrhythmia.