Based on the fact that the role of PTPN1 in tumor is still controversial,28 we speculated that the reason for the above paradox was due to the dramatic changes of gene expression profile between EGFR‐TKI sensitivity and resistance, which leads to the malignant behavior of cells mediated by differential molecules, and then causes the discrepant effects of PTPN1. This evidence concerns the gene PTPN1 and neoplasm.