Meanwhile, Shih et al. [63] established a BCP model using prostate cancer cells and demonstrated a time-dependent increase in pmTOR and its downstream effector molecule p-p70S6K in the spinal dorsal horn (L4-5) on the ipsilateral side of the carcinogenesis with the development of cancer pain, suggesting an important role of the PI3K–Akt–mTOR signaling pathway in BCP. This evidence concerns the gene MTOR and Familial prostate cancer.