The risk of being overweight or having obesity in patients with CD4 nadir of 0–200 cells/mm3 was 76% less than that of patients who had CD4 cell count ≥350 cell/mm3 (UOR = 0.24, p < 0.001), while in those with CD4 cell count of 201–349 cell/mm3it was 67% less than that of patients who had CD4 cell count ≥350 cell/mm3 (UOR = 0.33%, p < 0.001). Here, CD4 is linked to obesity due to melanocortin 4 receptor deficiency.