CD4 and systemic lupus erythematosus: To determine if reduced EZH2 expression with 2-DG treatment in SLE CD4+ T cells might be explained by an effect of 2-DG on the expression levels of miR-26a and miR-101, which regulate EZH2 and have been previously shown to be sensitive to glucose availability, we measured miR-26a and miR-101 levels in SLE CD4+ T cells with and without 2-DG treatment.