Considering the antioxidant potential of atorvastatin and the impact of the expression of NOX1 and Rac1 on oxidative stress and hepatic fibrogenesis, in this study, we attempted to assess whether the use of atorvastatin affects the expression of NOX1, Rac1-GTP, and Rac1 in BDL-induced cholestasis in rats. Here, RAC1 is linked to cholestasis.